Detalhe da pesquisa
1.
30 Years of Biotherapeutics Development-What Have We Learned?
Annu Rev Immunol
; 38: 249-287, 2020 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340579
2.
Bystanders not so innocent after all.
Immunity
; 36(6): 901-3, 2012 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22749349
3.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981576
4.
T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.
J Immunol
; 199(2): 613-623, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28584007
5.
Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression.
Blood
; 128(16): 2068-2082, 2016 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27488350
6.
IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice.
J Immunol
; 197(8): 3008-3017, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27619997
7.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830649
8.
Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.
Proc Natl Acad Sci U S A
; 111(38): 13942-7, 2014 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25201978
9.
Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.
Toxicol Appl Pharmacol
; 300: 47-54, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27078884
10.
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.
J Immunol
; 193(7): 3600-12, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25187652
11.
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
J Immunol
; 191(5): 2205-16, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23894201
12.
The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections.
Infect Immun
; 82(3): 1173-80, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24379290
13.
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.
J Exp Med
; 204(3): 481-7, 2007 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17353366
14.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642482
15.
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg Med Chem Lett
; 23(17): 5014-21, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23870430
16.
Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection.
J Exp Med
; 203(7): 1805-15, 2006 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16818672
17.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Bioorg Med Chem Lett
; 22(24): 7627-33, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23107482
18.
IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models.
PLoS One
; 17(9): e0274582, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36107926
19.
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.
J Exp Med
; 202(6): 761-9, 2005 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16157683
20.
IL-23 is required for protection against systemic infection with Listeria monocytogenes.
J Immunol
; 183(12): 8026-34, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19923464